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Retrieved Lemoine P, Zisapel N (2012). "Melatonin: action as antioxidant and potential applications in human disease and aging".

92 Commercial availability edit University of Helsinki pharmaceutical laboratory prepared melatonin available upon prescription Immediate-release melatonin is not tightly regulated in countries where it is available as an over-the-counter medication. A b c Hardeland R (February 2015). "Melatonin: an ancient molecule that makes oxygen metabolically tolerable". "Mechanisms regulating melatonin synthesis in the mammalian pineal organ". 54 Pharmacology edit Pharmacodynamics edit In humans, melatonin is a full agonist of melatonin receptor 1 ( picomolar binding affinity ) and melatonin receptor 2 (nanomolar binding affinity both of which belong to the class of G-protein coupled receptors (gpcrs).


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